Coronary artery disease refers to a condition caused by the coronary arteries being blocked or constricted.

Causes of Coronary Artery Disease

โรคหลอดเลือดหัวใจ HEART DISEASE

Coronary artery disease is the result of a buildup of plaque around the interior wall of the arteries, causing the lining of the arteries to thicken and become constricted. When this happens, the heart can’t pump as much oxygenated blood as required.

โรคหลอดเลือดหัวใจ HEART DISEASE

Over time, if a patient develops coronary artery disease, his or her blood vessels will no longer be able to supply sufficient oxygenated blood to the heart muscle, which can lead to sudden and severe chest pains or heart attack.

If there is a sudden blockage of the arteries caused by deposits of plaque, a rupture or a blood clot may then develop, resulting in a potentially fatal heart attack and other serious related complications.

Symptoms which should cause patients to consult their doctor

How are we using stem cells to understand and treat heart function and disease?

โรคหลอดเลือดหัวใจ HEART DISEASE

Researchers are using stem cells in two important ways to improve cardiac health.

First, they are turning stem cells into “heart muscle in a dish.” If patients have genetic causes of heart disease, their stem cell-derived heart muscle also will have this disease and this heart muscle can be used to discover new drugs.


Second, stem cells offer ways to replace damaged heart tissue. Using cellular therapy, researchers hope to repair or replace heart tissue damaged by congestive heart failure and heart attacks.

Unlike the treatments listed above, cellular therapy could provide a durable treatment for heart deficiencies, rather than symptom-focused treatment.

Your heart is constructed of several types of cells. For mending damaged heart tissue, researchers generally focus on three specific heart cell types:

โรคหลอดเลือดหัวใจ HEART DISEASE

Researchers are experimenting with a variety of stem cell therapies to transplant new cells, use tissue engineering to improve the survival or function of transplanted cells, and stimulate existing cells to generate new cardiomyocytes.

โรคหลอดเลือดหัวใจ HEART DISEASE

Researchers can grow cardiomyocytes in the lab from the following sources:

Strikingly, these stem cell-derived cardiomyocytes will beat in unison in a culture dish, the same way they do in a living heart muscle.

This property is essential, as researchers explore whether they might someday grow replacement tissue for transplantation into patients.

However, it is not yet known whether lab-grown cardiomyocytes will integrate or beat in unison with surrounding cells if they are transplanted into a beating human heart.

โรคหลอดเลือดหัวใจ HEART DISEASE

Cardiac cells made from iPS cells are also incredibly useful for creating human models of heart disease to better understand exactly what goes wrong and for testing different drugs or other treatments. They can also be used to help predict which patients might have toxic cardiac side effects from drugs for other diseases such as cancer.